Glossary

For a record to remain reliable, authentic, with its integrity maintained, and useable for as long as the record is needed, it is necessary to preserve its content, context, meaning, and sometimes its structure.A trustworthy record preserves the actual content of the record itself and information about the record that relates to the context in which it was created and used. Specific contextual information will vary depending upon the business, legal, and regulatory requirements of the business activity. The record’s reliability and authenticity may be impaired if its structure or arrangements are not preserved. The acronym ALCOA is used to summarize the key properties of a trustworthy record.

For a record to remain reliable, authentic, with its integrity maintained, and useable for as long as the record is needed, it is necessary to preserve its content, context, meaning, and sometimes its structure.A trustworthy record preserves the actual content of the record itself and information about the record that relates to the context in which it was created and used. Specific contextual information will vary depending upon the business, legal, and regulatory requirements of the business activity. The record’s reliability and authenticity may be impaired if its structure or arrangements are not preserved. The acronym ALCOA is used to summarize the key properties of a trustworthy record.

(ISO) An operation table for a logic operation.

A table that describes a logic function by listing all possible combinations of input values, and indicating, for each combination, the output value.

Protein-splitting enzyme derived from trypsinogen in the pancreatic juice. Used to remove adherent cells from a surface and to break up (digest) purified proteins for analysis.

Trypsin allows the growth of cells as independent microorganisms distinct from tissue culture by causing cell disaggregation. Excised tissue is softened and treated with a proteolytic enzyme, normally trypsin, then washed and suspended in a growth medium to produce a primary culture. Subculturing from the primary culture usually involves treatment with antitrypsin (such as serum) to produce a secondary culture. Cell lines are established by repeated culture through cycles of growth, trypsinization, and subculture. Trypsin is also used to remove anchorage-dependent cells from their attached substratum.

Quantitating the resultant fragments caused by tryptic digestion.

Tumor Surface Antigen

Telecommunication Systems Bulletin

Toxic Substances Control Act (EPA Regulations)

Transmissible Spongiform Encephalopathy

A type of brain disease generally believed to be caused by prions.

Chronic degenerative nervous diseases characterized by the accumulation of an abnormal isoform of a cellular glycoprotein known as PrP or prion protein. TSE diseases in animals include: bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep and goats, chronic wasting disease CWD) in cervids (deer and elk), transmissible mink encephalopathy (TME) in farmed mink, feline spongiform encephalopathy (FSE) in felidae (domestic cats and captive large cats), and spongiform encephalopathy of exotic ungulates in zoos.In humans, spongiform encephalopathies include different forms of Creutzfeldt-Jakob Disease (CJD), kuru, Gertsmann-Straussler Syndrome (GSS) and fatal familial insommnia (FFI).

Thermoset Polyurethane

Total Suspended Solids

Technology Testing and Evaluation Program

Tube is sized by its nominal outside diameter. For bioprocessing equipment, tube does not include pipe.

A cylindrical device used for the conveyance of fluid that is sized by its inside diameter dimension.

An abnormal growth of cells. Also defined as a circumscribed growth, not inflammatory in character, arising from preexisting tissue, but independent of the normal rate or laws of growth of such tissue, and subserving no physiological function.

Morphological and physiological changes associated with tumor growth.

Genes that normally restrain cell growth but, when missing or inactivated by mutation, allow cells to grow uncontrolled.

Rare metallic element with extremely high melting point (3410°C). Used in manufacturing TIG electrodes.