Glossary

An organism that has two identical alleles of a gene, one inherited from each parent.

A specific organic product, produced in one part of a plant or animal body, and transported to another part where, at low concentrations, it promotes, inhibits or quantitatively modifies a biological process.

A cell or organism used for growth of a virus, plasmid or other form of foreign DNA, or for the production of cloned substances.

(ICH Q5D)

The cells in which recombinant DNA is inserted so that it may be cloned as the host cells divide, so that the recombinant protein it codes for can be reproduced in large quantities.

An organism that contains a plasmid or virus. The host organism takes on the genetic functions of the plasmid or viral DNA.

The host is the organism into which a gene from another organism is transplanted. The guest gene is carried by a vector, which is a larger DNA molecule, such as a plasmid, or a virus into which that gene is genetically engineered and which then propagates in the host.NIH Guidelines under Appendix E. - Certified Host-Vector Systems contains a list of derivatives host-vector systems previously classified as Host-Vector 1 Systems or Host-Vector 2 Systems, they are: Bacillus subtilis, Saccharomyces Cerevisiae, Escherichia coli, Neurospora crassa, Streptomyces, and Pseudonomas putida.

Ratio of the hourly leakage q of the containment enclosure under normal working conditions (pressure and temperature) to the volume V of the said containment enclosure.NOTE: It is expressed in reciprocal hours (h-1).

Hewlett Packard

High Performance Anion Exchange (in HPLC)

Health Protection Bureau (Canadian equivalent of FDA)

High Performance Capillary Electrophoresis

Human Parainfluenza Virus

High Pressure Liquid Chromatography

Liquid chromatography performed at high pressures (as high as 8,000 psi) with small-particle packings (as small as 3µm in diameter). HPLC methods include reverse-phase, normal-phase, size-exclusion, ion-exchange, ion, chiral, hydrophobic-interaction, and hydrophilic-interaction chromatography. HPLC has been used since the late 1960s, whereas liquid chromatography has been in use since 1903.

Sometimes called high-performance liquid chromatography, is a separation technique based on a solid stationary phase and a liquid mobile phase. Separations (into distinct bands) are achieved by partition, adsorption, or ion-exchange processes, depending upon the type of stationary phase used. Each band is then profiled as the solvent flows through a UV detector, or by fluorescence, or refractive index detectors.

Hazardous Production Materials

Hydroxypropyl Methylcellulose

Highly Protected Risk

Health Products Regulation Group (Singapore)

Human Papilloma Virus

Highly Purified Water

Human Repeat Insult Patch Testing

Hormone Replacement Therapy