Glossary

An established line of human cervical carcinoma cells used to study the biochemistry and genetics of human cell growth.

Any structure with a spiral shape. The Watson and Crick model of DNA is in the form of a double helix.

A service, manual or electronic that is available to support issue resolution (access, systems failure, power outages, etc.) or forward them to the appropriate source for resolution.

An organization that acts a single point of contact between users and IT. They help users solve simple problems and facilitate solution of more complex issues by experts.

T cells that respond to an antigen displayed by a macrophage by stimulating B and T lymphocytes to develop into antibody-producing plasma cells and killer T cells, respectively.

Hydroxyethyl Methacrylate polymer

Clumping (agglutination) of red blood cells.

An iron protoporphyrin differing from heme in that the central iron atom is in the ferric (Fe+++) rather than the ferrous (Fe++) state; the prosthetic group of methemoglobin.

An unspecialized precursor cell that will develop into a mature blood cell.

Having only one copy of a particular gene. Foe example, in humans, males are hemizygous for genes found on the Y chromosome.

A device for counting blood cells.

The red, respiratory conjugated protein of erythrocytes, consisting of approximately 6 percent heme and 94 percent globin (a protein).

A hereditary, plasma-coagulation disorder, principally affecting males but transmitted by females and characterized by excessive, sometimes spontaneous, bleeding.

Pertaining to or related to the formation of blood cells.

High Efficiency Particulate Air (filtration)

Filters with a minimum efficiency of 99.97% for 0.3 µm particle size as determined by test. The test can be by the monodispersed dioctyl phthalate (DOP) method or other equally sensitive method. When operated at design velocity, larger and smaller particles are captured at higher efficiencies. HEPA filters are made of compressed and bonded micro-fiberglass or Teflon® corrugated to produce a high surface area in a small area panel of filter medium. Employed in unidirectional airflow benches, air handlers, and as terminal air supply filters in cleanrooms.

High Efficiency Particulate Air – A filter with an efficiency in excess of 99.97% for 0.3 micron particles.

A sulphur containing polysaccharide that stops blood from clotting by preventing the conversion of prothrombin to thrombin and by neutralizing thrombin. It is contained in the mast cells and is extractable from various tissues, notably the lung.

A toxin that is destructive to parenchymal (specific tissue) cells of the liver.

(ICH Q3A (R2)) Medicinal products containing, exclusively, plant material and/or vegetable drug preparations as active ingredients. In some traditions, materials of inorganic or animal origin can also be present.

Transfer of genetic information from parent cells to progeny.

A unit of frequency equal to one cycle per second.

Hazard Evaluation System and Information Service