Glossary

Acute Lymphoblastic Leukemia

Acute Lymphocytic Leukemia

The clear white portion of an egg. In influenza vaccine manufacturing, the virus is propagated in the embryonic chick and sloughed into the allantoic fluid that is harvested to produce the vaccine.

Allelomorph (adj: allelic, allelomorphic). One of a pair, or series, of variant forms of a gene that occur at a given locus in a chromosome. Alleles are symbolized with the same basic symbol (e.g., B for dominant and b for recessive); B1, B2, ..., Bn for n additive alleles at a locus). In a normal diploid cell there are two alleles of any one gene (one from each parent), which occupy the same relative position (locus) on homologous chromosomes. Within a population there may be more than two alleles of a gene.

A substance that causes an allergy.

An extract in a solvent of a substance that causes an allergic reaction. They are relative crude drugs by contemporary standards and are manufactured by specialty companies and in some cases, by a practicing allergist. Also, allergenic extracts are generally difficult to filter since they most frequently are extracts of natural substances such as foods, house dust, animal hair, etc.

Allergenic products are biological products which are administered to man for the diagnosis, prevention, or treatment of allergies [21CFR 680.1(a)] and include Allergenic Extracts and Allergen Patch Tests.

A reaction to a substance that occurs through a change in the immune system caused by the production of antibodies, and usually experienced by only a small number of people exposed to a substance. Allergic reactions in the workplace tend to affect the skin (Dermatitis) and lung (Asthma).

Involving cells or tissues that are genetically dissimilar and therefore immunologically incompatible, although from individuals of the same species.

Use the word Allogeneic when describing a cell & gene therapy that uses cells that are not the same as the patient’s own cells.  The product(s) that result are used on a variety of people and tend to be produced in larger batches.

Steel containing substantial quantities of elements other than carbon and the commonly accepted limited amounts of manganese, sulfur, silicon, and phosphorus. Addition of such alloying elements is usually for the purpose of increased hardness, strength or chemical resistance. The metals most commonly used for forming alloy steels are: nickel, chromium, silicon, manganese tungsten, molybdenum and vanadium, Low Alloy steels are usually considered to be those containing a total of less than 5% of such added constituents.

A coil or spiral element of protein secondary structure.

Acceptance testing performed by the customer in a controlled environment at the developer's site. The software is used by the customer in a setting approximating the target environment with the developer observing and recording errors and usage problems.

Pertaining to a character set that contains letters, digits, and usually other characters such as punctuation marks.

Autoimmune Lymphoproliferative Syndrome

Amyotropic Lateral Sclerosis

Automatic Liquid Sampler

American Lumber Standards Committee

Alanine Transaminase

Different ways of combining a gene’s exons to make variants of the complete protein.

Arithmetic Logic Unit

Aluminum sulfate, commonly added during municipal water treatment to cause insoluble colloids to coalesce into larger particles that can be removed by settling.

Automatic Loading Unloading System

A disease that causes memory loss, personality changes, dementia and, ultimately, death. Not all cases are inherited, but genes have been found for familial forms of Alzheimer’s disease.

Agricultural Marketing Act of 1946 (USDA)

American Medical Association